Ketones improve cognition in patients with type 2 diabetes

Effects of β-hydroxybutyrate on cognition in patients with type 2 diabetes.

Study Summary

In this study 18 type 2 diabetic patients received either and IV infusion of ketone bodies or a placebo (saline solution).
A neuropsychological test battery was then used to compare cognition between the 2 groups.
Working memory significantly improved in the ketone group

Interpretation

Cognitive decline and Alzheimer’s has recently been called type 3 diabetes because of the association between elevated blood glucose levels and memory impairment. It has been hypothesized that insulin resistance in the brain is one of the mechanisms involved. This is because insulin resistance both impairs glucose uptake (lack of energy to the brain) and elevates blood glucose (diabetes).
Ketones serve as an alternative fuel for the brain. As this study demonstrates, ketones can compensate for the glucose/energy deficit in the brain. Ketones can provide at least some of the energy needed for brain function without the need for glucose or insulin .

Citation

https://www.ncbi.nlm.nih.gov/pubmed/31821157
PMID: 31821157 DOI: 10.1530/EJE-19-0710

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